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KMID : 0438219750120010213
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Korea University Medical Journal
1975 Volume.12 No. 1 p.213 ~ p.226
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Experimental Intracameral Administration of Autonomic Drugs
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Abstract
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This study was undertaken to observe the effects and side effects of autonomic drugs which were introduced into the anterior chamber of rabbit.
The intracameral injection in one eye and the conjunctival instillation in the other eye of each rabbit (among 31 rabbits) were performed with 1% atropine ophthalmic ointment, 1% atropine solution, 5% homatropine solution, 1% tropicamide solution, 10% phenylephrine solution, 2% pilocarpine ophthalmic ointment and 1% pilocarpine solution (0.05ml each).
The following results were obtained:
1 . In mydriatics group;
a) Maximal pupillary diameter was larger in case of conjunctival instillation than in case of intracameral injection.
b) Duration of mydriasis was longer in case of intracameral injection than in case of conjunctival instillation.
c) In 1% tropicamide group and 10% phenylephrine group, the time required for maximal mydriasis was shorter in case of intracameral injection; in the other groups it was shorter in case of conjunctival instillation.
1. In miotics group:
a) Minimal pupillary diameter was smaller in case of intracameral injection than in case of conjunctival instillation.
b) Duration of miosis was longer in case of intracameral injection.
c) The time required for minimal pupillary diameter was shorter in case of intracameral injection.
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